Univerisity of New Mexico: The Center for High
Postdoctoral positions available
Post-doctoral position available to work on the role of microRNAs and RNA-binding proteins in addiction-related gene expression. Department of Neurosciences, University of New Mexico-Health Sciences Center
Project abstract
Post-transcriptional mechanisms play a vital role in the control of gene expression, yet, their role in the establishment of addictive behaviors has received very little attention One of the most studied cis-acting elements is the AU-rich element (ARE) present in the 3’untranslated region (3’UTR) of several unstable mRNAs. These sequences are targets of RNA-binding proteins such as the neuronal-specific and plasticity-associated RNA-binding protein HuD. We have recently identified a microRNA that binds to the same sequences in the 3’ UTRs of two mRNAs that are associated with mechanisms of addiction, BDNF and GAP-43 that are recognized by HuD. Given that the overlap between sequences recognized by RNA-binding protein HuD and microRNAs and the overrepresentation of these sites in the 3’ UTRs of addiction-related genes (ARGs), we propose that RNA-binding proteins such as HuD could compete with microRNAs for the post-transcriptional control of genes associated with substance abuse. To test this hypothesis we propose to experimentally test the functional competition between RNA-binding proteins and miRNAs in vitro and to assess the significance of these interactions in vivo in an animal model of cocaine-self-administration.
Desired expertise:
Preference will be given to qualified investigators with expertise in RNA biology, RNA-binding proteins and/or posttranscriptional gene regulation. Experience using RT-qPCR methods, in vitro RNA-binding assays, tissue culture and microRNAs/siRNAs is desired.
To apply:
Please send letter of application, 2 references and CV to
Dr. Nora Perrone-Bizzozero
Department of Neuroscience
University of New Mexico School of Medicine
1 University of New Mexico
Albuquerque NM 87131-001
Tel: 505-272-1165
FAX: 505-272-8082
E-mail: nbizzozero@salud.unm.edu
http://www.unm.edu/~neurohsc/perrone.htm
UNM is an equal opportunity employer.
Postdoctoral Position in to study mitochondrial dysfunction in neuronal injury.
A postdoctoral position is now available to study mechanisms of neuronal injury in brain slice models. This position is funded by a grant from the National Institutes of Health and involves a combination of cellular imaging and electrophysiology in hippocampal slices, to study initiation and consequences of spreading depression. Studies will include measures of mitochondrial function in neurons and astrocytes. A summary of our ongoing research is available at the following webpage (http://www.unm.edu/~neurohsc/shuttle.htm). Individuals with experience in brain slice studies, or studies of neuronal metabolism are particularly encouraged to apply.
If interested, please contact:
Bill Shuttleworth, Ph.D.
Associate Professor
Department of Neurosciences,
Email: bshuttleworth@salud.unm.edu
Postdoctoral Position in Molecular Neurogenetics of Synaptic Transmission