NORA I. PERRONE-BIZZOZERO, Ph.D.Professor |
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Research
Interests:
Posttranscriptional regulation of neuronal genes during brain development, nerve regeneration and synaptic plasticity. Synaptic protein regulation in schizophrenia, fetal alcohol syndrome and alcoholism. GABA and NMDA receptor dysfunction and altered myelination in schizophrenia. Neurogenomics and the genetics of schizophrenia.
Selected Publications:
Perrone-Bizzozero, N. I. Cansino, V. V. and Kohn, D. T. (1993) Post-transcriptional regulation of GAP-43 gene expression in PC12 cells through PKC-dependent stabilization of the mRNA. J. Cell. Biol. 120: 1263-1270.
Perrone-Bizzozero, N.I., Sower, A.C., Bird, E.D., Benowitz, L.I., Ivins, K. and Neve, R.L. (1996) Levels of the growth associated protein GAP-43 are selectively increased in association cortices in schizophrenia. Proc. Nat. Acad. Sci. 93:14182-14187.
Tsai, K-C, Cansino, V.V., Neve R.L. and Perrone-Bizzozero N.I. (1997) Post-transcriptional regulation of the GAP-43 gene during neuronal differentiation by specific sequences in the 3' untranslated region of this mRNA. J. Neurosci. 17:1950-1958.
Perrone-Bizzozero, N.I., Isaacson, T.V., Keidan, G. M.D, Eriqat, C., meiri, K.F., Savage, D.D., and Allan, A.M. (1998) Prenatal ethanol exposure decreases GAP-43 phosphorylation in the hippocampus of adult rat offspring. J. Neurochem. 71:2104-2111
Perrone-Bizzozero, N. and F. Bolognani (2002) Role of HuD and other RNA-binding proteins in neural development and plasticity.Journal of Neuroscience Research 68:121-126
Beckel-Mitchener, A.C.,
A. Miera, R. Keller, and N. Perrone-Bizzozero (2002) Poly(A) tail length dependent
stabilization of GAP-43 mRNA by the RNA binding protein HuD.
J. Biol. Chem. 12(4):457-64 .
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Anderson KD, Merhege MA, Morin M, Bolognani F, Perrone-Bizzozero NI. (2003)
Increased expression and localization of the RNA-binding protein HuD and GAP-43
mRNA to cytoplasmic granules in DRG neurons during nerve regeneration. Exp
Neurology. 183(1):100-8;
Tanner, D.C., AW Githinji, M Garcia, EA Young, DD Savage, and NI Perrone-Bizzozero. Fetal Alcohol Exposure Alters GAP-43 Phosphorylation and Protein Kinase C Responses to Contextual Fear Conditioning in the Hippocampus of Adult Rat Offspring Alcoholism: Clinical and Experimental Research. 2004 Jan;28(1):113-22.
Chambers, J.S. and Perrone-Bizzozero, N.I. (2004) Altered Myelination of the Hippocampal Formation in Subjects with Schizophrenia and Bipolar Disorder. Neurochem Res. 29:2293-2302.
Bolognani, F., Merherge, M., Twiss, J. and Perrone-Bizzozero, N.I. (2004) Dendritic Localization of the RNA-binding Protein HuD in Hippocampal Neurons: Association with Polysomes and Upregulation During Contextual Learning. Neurosci. Lett. 371: 152-157.
Bustillo,l J., Barrow, R., Paz, R., Tang, J., Seraji-Bozorgzad, N., Moore , G., Bolognani, F., Lauriello J , Perrone-Bizzozero N. I, Matthew, P. and Galloway, M (2006). Long term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels, Neuropsychopharmacology, 31:751-756.
Bolognani, F., Tanner, D.C., Merhege, M., Jasmin, B. and Perrone-Bizzozero, N.I. (2006) In vivo post-transcriptional regulation of the GAP-43 mRNA by overexpression of the RNA-binding protein HuD. J. Neurochem, 96:790-801 .
Paz, R.D., Andreasen , N.C. , Daoud, S., Roberts, R., Conley, R., Bustillo, J., and Perrone-Bizzozero, N.I. Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia. Am J Psychiatry, 163(10):1829-31..
Bolognani F, Qiu S, Tanner DC, Paik J, Perrone-Bizzozero NI, Weeber EJ. (2007) Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD. Neurobiol Learn Mem 87:635-43.
Deschenes-Furry J, Mousavi K, Bolognani F, Neve RL, Parks RJ, Perrone-Bizzozero NI, Jasmin BJ. (2007) The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy. J Neurosci. 27:665-75. Selected for This Week in the Journal Editorial section.
Bolognani F, Tanner DC, Nixon S, Okano HJ, Okano H, Perrone-Bizzozero NI. Coordinated Expression of HuD and GAP-43 in Hippocampal Dentate Granule Cells During Developmental and Adult Plasticity. Neurochem Res. 2007 Jun 19; [Epub ahead of print]
Bolognani, F and Perrone-Bizzozero, NI. RNA-protein interactions and the control of mRNA stability in neurons. J Neurosci Res. 2008 Feb 15; 86( 3): 481-9. Review.
Tanner DC, Qiu S, Bolognani F, Partridge LD, Weeber EJ, Perrone-Bizzozero NI. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus. 18(8):814-23 2008 .
Liu J, Pearlson G, Windemuth A, Ruano G, Perrone-Bizzozero NI, Calhoun V. Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA. Hum Brain Mapp. 2007 Dec 10. [Epub ahead of print]
W. Michael Bullock, Karen Cardon, Juan Bustillo, M.D., Rosalinda Roberts Ph.D., Nora I. Perrone-Bizzozero, Ph.D. Altered Expression of Genes Involved in GABAergic Transmission and Neuromodulation of Granule Cell Activity in the Cerebellum of Patients with Schizophrenia. American J. Psychiatry, in press.
Selected Book Chapters:
Perrone-Bizzozero, N.I. and Keller, R. (2002) Post-transcriptional regulation of the GAP-43 gene. In RNA binding proteins, Sandberg and Mulroney Eds., Chapter 9, pp. 157-175, Kluwer Academic Press.
Perrone-Bizzozero, N.I. and Tanner, D. (2005) GAP-43 in Neural Development and Plasticity. In The Handbook of Neurochemistry and Molecular Neurobiology (3 rd Edition). Volume 9, Springer.
Perrone-Bizzozero, NI and Bullock, W. M. (2008) Biological mechanisms of schizophrenia. Wiley Encyclopedia of Chemical Biology, John Wiley & Sons, Inc, in press.
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E-mail to Dr. Perrone-Bizzozero |
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